GHK-Cu
In simple terms, GHK-Cu is a peptide that helps the body: repair skin, heal wounds, improve hair growth.
Product Details
| Parameter | Specification |
| Purity | High-purity research grade |
| Form | Lyophilized peptide powder |
| Content | 100 mg GHK-Cu per vial |
| Packaging | Glass vial with sterile closure |
| Storage Conditions | Store lyophilized at 2–8 °C (desiccated, protect from light) |
| Molecular Formula | C₁₄H₂₄CuN₆O₄ |
| Molecular Weight | ~404.9 g·mol⁻¹ |
| Amino Acid Sequence | Gly-His-Lys (Cu²⁺ complex) |
| CAS Number | 49557-75-7 |
| Solubility | Bacteriostatic water |
Overview
GHK-Cu (glycyl-L-histidyl-L-lysine–copper complex) is a naturally occurring copper-binding tripeptide first identified in human plasma. It is a complex formed between the GHK peptide and copper ions (Cu²⁺), playing a key role in tissue regeneration, skin remodeling, and gene regulation. It is one of the most extensively studied peptides in: dermatology and skin repair, wound healing, anti-aging research (Pickart & Margolina, 2018).
What it is and how it works
GHK-Cu acts as a copper carrier molecule, delivering copper ions into cells and activating multiple biological processes. Mechanisms include: stimulation of fibroblasts, increased synthesis of collagen, elastin, and GAGs, modulation of matrix metalloproteinases (MMPs), activation of antioxidant enzymes (e.g., SOD), regulation of gene expression (Pickart, 2008).
Effects confirmed by research
1. Skin regeneration and anti-aging
- increases collagen production, improves elasticity, reduces wrinkles, restores extracellular matrix (Pickart et al., 2015).
2. Wound healing
- promotes angiogenesis, accelerates tissue repair, reduces inflammation (Maquart et al., 1988).
3. Hair growth
- stimulates hair follicles, prolongs growth phase, improves scalp circulation (Pickart, 2008).
4. Anti-inflammatory and antioxidant effects
- reduces inflammatory cytokines, enhances antioxidant activity, protects against oxidative stress (Pickart & Margolina, 2018).
5. Gene expression regulation
- activates regenerative genes, suppresses inflammatory genes, affects thousands of genes.
Scientific description
From a scientific standpoint, GHK-Cu is: a copper-binding peptide, a regulator of: collagen synthesis, angiogenesis, gene expression, antioxidant defense.
References
Pickart, L., Margolina, A. GHK-Cu peptide and regeneration. BioMed Research International. 2018. Pickart, L. GHK and tissue remodeling. Journal of Biomaterials Science. 2008. Pickart, L., et al. Copper peptides in skin aging. Dermatologic Surgery. 2015. Maquart, F. X., et al. Collagen synthesis stimulation by GHK-Cu. FEBS Letters. 1988. Pickart, L. Copper peptides and hair biology. Experimental Dermatology. 2008.
