MOTS-c
In simple terms, MOTS-c is a signal produced by mitochondria that helps the body: use energy more efficiently, improve metabolism, adapt to stress.
Product Details
| Parameter | Specification |
| Purity | ≥ 99% (99.8% purity, HPLC, third-party tested) |
| Form | Lyophilized peptide powder |
| Content | 10 mg MOTS-c per vial |
| Packaging | Glass vial with sterile closure |
| Storage Conditions | Store lyophilized at −20 °C (desiccated, protected from light) |
| Molecular Formula | C101H152N28O22S2 |
| Molecular Weight | ≈ 2174.6 g·mol⁻¹ |
| Amino Acid Sequence | MRWQEMGYIFYPRKLR |
| CAS Number | 1627580-64-6 |
| Solubility | Bacteriostatic water |
Overview
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a 16-amino-acid peptide belonging to the class of mitochondrial-derived peptides (MDPs). It is encoded within the mitochondrial genome, specifically from the 12S rRNA region. From a scientific perspective, MOTS-c represents a unique signaling molecule linking: mitochondrial function, nuclear gene regulation, and metabolic homeostasis. It is increasingly recognized as a key regulator of: energy metabolism, insulin sensitivity, and metabolic stress adaptation (Lee et al., 2015).
What it is and how it works
Unlike classical peptides encoded by nuclear DNA, MOTS-c is mitochondrially encoded, allowing it to function as a signal from mitochondria to the nucleus. Its mechanism includes: translocation to the nucleus under metabolic stress, regulation of gene expression, activation of AMPK (AMP-activated protein kinase), and modulation of glucose and lipid metabolism. Thus, MOTS-c acts as a metabolic regulator enabling cells to adapt to energy stress (Lee et al., 2015; Kim et al., 2018).
Effects confirmed by research
1. Insulin sensitivity and glucose metabolism
- MOTS-c improves: glucose utilization, insulin signaling, resistance to metabolic dysfunction (Lee et al., 2015).
2. Energy metabolism
- Through AMPK activation, MOTS-c: enhances fat oxidation, improves metabolic efficiency, increases energy balance (Hardie et al., 2012).
3. Body weight and fat regulation
- Preclinical data show: reduced weight gain, improved fat distribution, enhanced metabolic profile.
4. Physical performance
- MOTS-c has been shown to: improve endurance, enhance metabolic adaptation (Reynolds et al., 2021).
5. Aging and longevity
- declines with age, linked to metabolic aging, associated with longevity genetics (Fuku et al., 2015).
Scientific description
From a scientific standpoint, MOTS-c is: a mitochondrial-encoded peptide, regulator of AMPK signaling, modulator of metabolic homeostasis.
References
Lee, C., et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis. Cell Metabolism. 2015. Kim, K. H., et al. MOTS-c regulates nuclear gene expression. Nature Communications. 2018. Reynolds, J. C., et al. MOTS-c enhances physical performance. Nature Communications. 2021. Fuku, N., et al. MOTS-c and longevity. Aging Cell. 2015. Hardie, D. G., et al. AMPK and metabolism. Nature Reviews Molecular Cell Biology. 2012.
